Global Network Alignment
نویسندگان
چکیده
منابع مشابه
Global Network Alignment
Motivation: High-throughput methods for detecting molecular interactions have lead to a plethora of biological network data with much more yet to come, stimulating the development of techniques for biological network alignment. Analogous to sequence alignment, efficient and reliable network alignment methods will improve our understanding of biological systems. Network alignment is computationa...
متن کاملGlobal Network Alignment
Finding the common ancestries of different proteins across species is an important task. Homologs is the basic definition which denotes two genes that have descended from some common ancestral. For a more focused notation, we define Paralogs if the last evolutionary event separating the genes was duplication, and similarly we define Orthologs if the last evolutionary event separating the genes ...
متن کاملLocal versus global biological network alignment
MOTIVATION Network alignment (NA) aims to find regions of similarities between species' molecular networks. There exist two NA categories: local (LNA) and global (GNA). LNA finds small highly conserved network regions and produces a many-to-many node mapping. GNA finds large conserved regions and produces a one-to-one node mapping. Given the different outputs of LNA and GNA, when a new NA metho...
متن کاملGlobal network alignment using multiscale spectral signatures
MOTIVATION Protein interaction networks provide an important system-level view of biological processes. One of the fundamental problems in biological network analysis is the global alignment of a pair of networks, which puts the proteins of one network into correspondence with the proteins of another network in a manner that conserves their interactions while respecting other evidence of their ...
متن کاملMAGNA: Maximizing Accuracy in Global Network Alignment
MOTIVATION Biological network alignment aims to identify similar regions between networks of different species. Existing methods compute node similarities to rapidly identify from possible alignments the high-scoring alignments with respect to the overall node similarity. But, the accuracy of the alignments is then evaluated with some other measure that is different than the node similarity use...
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ژورنال
عنوان ژورنال: Nature Precedings
سال: 2010
ISSN: 1756-0357
DOI: 10.1038/npre.2010.4505.1